Stemphylium and Ulocladium between Benefit and Harmful

Background: Emerging of microbial resistance, spread life-threatening diseases, and biological control pathogens destroying economically important crops, are serious problems that encourage scientists to search for unusual sources novel compounds with activities. Fungi promising such due their ability produce variety secondary metabolites could be, if truly investigated, the solution currently problems. Aim: The aim this review is highlight diversity produced by endophytic Stemphylium Ulocladium represents biologically diverse metabolites. Materials methods: This was a narrative review. A comprehensive literature done using PubMed, Google Scholar, Scopus, EMBASE keywords, Stemphylium; Ulocladium; Secondary metabolites; Results: Many studies reported especially, atrum Preuss, showed biocontrol activity against Botrytis cinerea on crops cultivated in greenhouse field. fungus globuliferum isolated from stem tissues Moroccan medicinal plant Mentha pulegium. Extracts exhibited significant cytotoxicity when tested vitro L5178Y cells. Conclusion: Endophytic fungi noble consistent source unique natural mixtures high level biodiversity may also yield several pharmaceutical significance, which attracting scientific surveys worldwide. Every study conducted resulted discovery new or pointing possible application, made species potential pharmaceuticals attracted attention further investigations control.